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EC number: 242-060-2
CAS number: 18172-67-3
The water solubility was determined by the slow-stirring method.The water solubility of (-)-beta-pineneis 6.95 mg/L at 20 °C.
A recent study was
performed in order to determine the water solubility of (-)-beta-pinene
(Madru, 2013). In this study, the water solubility of (-)-beta-pinene
was determined to be 6.95 mg/L using the slow-stirring method (at 20°C
and pH 4-7), which is the preferred method for this kind of substances.
This value is retained to be used as Key value for the chemical safety
assessment. This result is supported by literature data on beta-pinene,
which could have been slightly overestimated due to the methods used:
8.06 mg/L (Copolovici, 2005: geometric mean of three literature values),
11.03 mg/L (Fichan, 1999 : two liquid phase contact methods giving an
emulsion treated in 2 ways, settling and centrifugation); 12.7 mg/L
(Tamura, 2005: close to the flask method not suitable for low solubility
It must be noted that
the study performed in 2010 to determine the water solubility of
(-)-beta-pinene using the elution method, led to a water solubility
value ≤ 0,02 mg/L at 20ºC and pH 8. After re-examination, this study is
considered as not reliable and is disregarded for the following reasons:
-The water solubility
measured at 20°C (≤ 0.02mg/L) in this study, is not consistent with
previously reported values for beta-pinene: 11.03 mg/L (Fichan, 1999);
12.7 mg/L (Tamura, 2005) and 8.06 mg/L (Copolovici, 2005) and with the
result of the Madru’s recent study on (-)-beta-pinene (slow-stirring,
6.95 mg/L at 20°C).
-The mean values
obtained from the three consecutive tests conducted with different flow
rates differed by more than 30%. Therefore, according to the OECD 105
guideline criteria, the study is not valid. The water solubility
decreased, when the water flow rate decreased. This can be explained by
an insufficient quantity of the test item loaded on the support
material, leading to erroneous results.
Therefore, the water
solubility value of (-)-BETA PINENE found in the more recent study (6.95
mg/L) is considered as the most accurate and is selected to be used as key
value for the chemical safety assessment of this substance.
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