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EC number: 242-060-2
CAS number: 18172-67-3
Solubility of (-)-beta-pinene in water
The water solubility of (-)-beta-pinene was
determined to be 6.95 mg/L by the slow-stirring method. This is the most
appropriate method for the determination of the water solubility of this
Poorly water-soluble substances are
substances with a limit of water solubility below 100 mg/L according to
OECD Guidance No 23 (2000) on aquatic toxicity testing of difficult
substances and mixtures. Therefore, (-)-beta pinene meets the definition
of poorly water soluble substances and has to be considered as a
"difficult substance to test".
Volatility of (-)-beta-pinene from
The Henry’s law constant (H) for a substance
is a measure of its equilibrium between an ideal solution phase and the
vapour phase. As such it is a measure of the potential for a substance
to be lost from solution by evaporation (OECD GD No 23). As an
approximation, if H is greater than 100 Pa.m3/mol, more than
50% of the substance could be lost from the water phase in 3-4 hours
(Mackay, 1992 cited by OECD GD No 23).
The H constant is estimated by: H = VP*MOLW
/ SOL (ECHA Guidance on information requirement R.16). Considering the
water solubility of 6.95 mg/L and vapour pressure of 519 Pa, this gives
a Henry’s Law constant of 10173 Pa.m3/mol. This result
provides evidence that the substance is difficult to test for aquatic
toxicity. The highest concerns are media preparation and maintaining
required exposure concentrations, due to low water solubility and
volatilisation from the test solutions.
The following precautions were therefore
taken to reduce the loss of test substance:
• study design: flow-through or semi-static
for fish and Daphnia tests,
• closed system with minimising headspace,
• analytical determination of exposure
Measured acute data
Reliable short-term toxicity data are
provided for the registered substance for three trophic levels (fish,
The relevant values are:
Fish: 96h-LC50= 0.502 mg/L (Pimephales
promelas, measured concentrations), 96h-LC50= 0.557 mg/L (Cyprinus
Daphnia magna: 48h-EC50=
1.250 mg/L (measured concentrations), 48h-EC50= 1.248 mg/L
Algae: 48h-EC50= 0.826 mg/L (Pseudokirchneriella
subcapitata, measured concentrations)
Predicted acute data
Fish: 96h-LC50= 0.68 mg/L
Daphnia: 48h-EC50= 1.09 mg/L
Algae: 72h-EC50= 0.70 mg/L
The predictions are obtained with QSAR
for the Mode of Action 1, based on validated data derived from standard
toxicity test, for which the concentrations of the test item had been
determined by chemical analyses over the test period. The predictions
are sufficiently robust, and are appropriate for the purposes of
chemical safety assessment required for REACH.
Based on this results, (-)-beta-pinene is
- dangerous for the environment according to
Directive 67/548/EEC "R50/53: very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment"
- and hazardous to the aquatic environment
under Regulation (EC) No 1272/2008 (CLP) - Category Acute 1 and Category
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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