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Diss Factsheets
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EC number: 242-060-2 | CAS number: 18172-67-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1966
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well described and well performed study with minor deviations: no data on signs and symptoms of toxicity
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 966
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Maximization test for identification of contact allergens by human assay (Kligman, 1966)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Turpentine, oil
- EC Number:
- 232-350-7
- EC Name:
- Turpentine, oil
- Cas Number:
- 8006-64-2
- IUPAC Name:
- 8006-64-2
- Reference substance name:
- Turpentine, oil (gum)
- IUPAC Name:
- Turpentine, oil (gum)
- Details on test material:
- Name of test material (as cited in study report): Turpentine
Constituent 1
Constituent 2
Method
- Type of population:
- other: prisoners
- Subjects:
- - Number of subjects exposed: 25
- Sex: Male
- Age: 18-50 years
- Race: Negroes (90% of experimental subjects) - Controls:
- No data
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: Patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Description of patch: Patch material is a nonwoven, highly absorbent, cloth, prepared by Curity under the trade name of Webril
- Vehicle / solvent: Petrolatum
- Concentrations: 50% (induction concentration) and 20% (Challenge concentration)
EXAMINATIONS
- Grading/Scoring system: Maximization grading:
Sensitization rate 0-2/25- Grade1- Weak sensitizer
Sensitization rate 3-7/25- Grade 2- Mild sensitizer
Sensitization rate 8-13/25- Grade 3- Moderate sensitizer
Sensitization rate 14-20/25- Grade 4- Strong sensitizer
Sensitization rate 21-25/25- Grade 5- Extreme sensitizer
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 18
- Number of subjects with negative reactions: 7
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, turpentine was considered to be a strong sensitizer (Grade 4) in humans.
- Executive summary:
In a study performed to assess the contact sensitization potential of turpentine by maximization test in humans, panels of 25 healthy adult male Negroes were induced with five exposures of dermal dose of 50% of turpentine in petrolatum for 48 hours using an occlusive patch followed by challenge dose of 20%. The challenge reaction was read immediately after removal of the 48 hour patch and again in another two days. An evident erythema was considered a minimum positive response. Sensitization potential was rated according to grading system as described in the report.
A total of 18 out of 25 subjects showed positive reaction to sensitization during the study.
Under the test conditions, turpentine was considered to be a strong sensitizer (Grade 4) in humans.
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