Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 434-850-2 | CAS number: 1680-31-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
In accordance with OECD guideline 417 a study was performed in order to assess the absorption, distribution, metabolism and excretion of Dioctylcarbonate after single oral administration to rats. Taken together, the findings of the study strongly suggest that neither the sexual organs nor other tissues and organs were relevantly exposed to unchanged Dioctylcarbonate.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
In accordance with OECD guideline 417 a study was performed in order to assess the absorption, distribution, metabolism and excretion of Dioctylcarbonate after single oral administration to rats. Taken together, the findings of the study strongly suggest that neither the sexual organs nor other tissues and organs were relevantly exposed to unchanged Dioctylcarbonate.
14C-Dioctylcarbonate after oral administration at dose levels of 100 and 1000 mg/kg, respectively, was very rapidly and efficiently degraded into radiolabelled C02. The degradation may have occurred already within the acidic pH of the stomach as well as metabolically after absorption of the test item.
Most of the test item remains at the skin surface, a small amount migrates into the Stratum corneum and an even smaller amount enters the deeper skin layers.
Discussion on bioaccumulation potential result:
In accordance with OECD guideline 417 a study was performed in order to assess the absorption, distribution, metabolism and excretion of Dioctylcarbonate after single oral administration to rats. Taken together, the findings of the study strongly suggest that neither the sexual organs nor other tissues and organs were relevantly exposed to unchanged Dioctylcarbonate.
14C-Dioctylcarbonate after oral administration at dose levels of 100 and 1000 mg/kg, respectively, was very rapidly and efficiently degraded into radiolabelled C02. The degradation may have occurred already within the acidic pH of the stomach as well as metabolically after absorption of the test item.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
