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Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
In accordance with OECD guideline 417 a study was performed in order to assess the absorption, distribution, metabolism and excretion of Dioctylcarbonate after single oral administration to rats. Taken together, the findings of the study strongly suggest that neither the sexual organs nor other tissues and organs were relevantly exposed to unchanged Dioctylcarbonate.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

In accordance with OECD guideline 417 a study was performed in order to assess the absorption, distribution, metabolism and excretion of Dioctylcarbonate after single oral administration to rats. Taken together, the findings of the study strongly suggest that neither the sexual organs nor other tissues and organs were relevantly exposed to unchanged Dioctylcarbonate.

14C-Dioctylcarbonate after oral administration at dose levels of 100 and 1000 mg/kg, respectively, was very rapidly and efficiently degraded into radiolabelled C02. The degradation may have occurred already within the acidic pH of the stomach as well as metabolically after absorption of the test item.

Most of the test item remains at the skin surface, a small amount migrates into the Stratum corneum and an even smaller amount enters the deeper skin layers.

Discussion on bioaccumulation potential result:

In accordance with OECD guideline 417 a study was performed in order to assess the absorption, distribution, metabolism and excretion of Dioctylcarbonate after single oral administration to rats. Taken together, the findings of the study strongly suggest that neither the sexual organs nor other tissues and organs were relevantly exposed to unchanged Dioctylcarbonate.

14C-Dioctylcarbonate after oral administration at dose levels of 100 and 1000 mg/kg, respectively, was very rapidly and efficiently degraded into radiolabelled C02. The degradation may have occurred already within the acidic pH of the stomach as well as metabolically after absorption of the test item.