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EC number: 270-128-1
CAS number: 68411-46-1
of results of thein vitromicronucleus test in human lymphocytes
95% Ctrl limit
Exposure period 4 hrs without S9 mix
0.06 – 1.19
3.92 – 25.34
Exposure period 20 hrs without S9 mix
0.00 – 1.11
1.47 – 5.89
Exposure period 4 hrs with S9 mix
0.08 – 1.38
0.70 – 10.20
the positive control groups and the test item treatment groups the
values are related to the solvent controls
number of micronucleated cells was determined in a sample of 2000
separation occurred at the end of treatment
number of micronucleated cells is statistically significantly higher
than corresponding control values
calculated as the CBPI is equal or higher than the solvent control value
2 MMC 0.8
3 Demecolcine 50
4 CPA 17.5
Statistical significance was confirmed by the Chi square test (α <
0.05), using a validated test script of “R”, a language and environment
for statistical computing and graphics. Within this test script a
statistical analysis was conducted for those values that indicated an
increase in the number of cells with micronuclei compared to the
concurrent solvent control.
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