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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The value for the log Pow of DBMC is cited in various reliable literature sources such as the SIDS report (2000) or in the EPIWIN programme, but the original study report of the experimental determination is not available. Hence the value for the partition coefficient of DBMC/Vulkanox is reliable with restrictions.
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
6.25
Temp.:
20 °C
Remarks on result:
other: pH not reported
Details on results:
Not reported

The partition coefficient of DBMC is 6.25 at 20 °C as determined experimentally with the shake flask method.

Conclusions:
The log Pow is experimentally determined to be 6.25 at 20 °C.
Executive summary:

The partition coefficient log Pow of DBMC is 6.25 at 20 °C as determined experimentally with the shake flask method.

Description of key information

Three data sources delivered similar partition coefficient values (MITI Japan, 1992; Bayer, 1989). In agreement with CITI Japan, 1992; LANXESS SDS, 2009; Merck SDS, 2006; PBT Working Group, 2009; ChemIDplus, 2009, the log Pow value of 6.25 at 20 °C as determined with the shake-flask method was used for the CSA.

Key value for chemical safety assessment

Log Kow (Log Pow):
6.25
at the temperature of:
20 °C

Additional information