Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: inhalation
Remarks:
other: repeated dose
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: study data do not give sufficient experimental details

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959

Materials and methods

Principles of method if other than guideline:
other: repeated dose, inhalation
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
other: rats, guinea pigs, dogs
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
not specified
Duration of treatment / exposure:
60 exposures over a period of 84 d
Frequency of treatment:
no data
No. of animals per sex per dose:
no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

No significant signs of toxicity were observed throughout the study.

Applicant's summary and conclusion

Executive summary:

Repeated dose inhalation study with animals, no signs of toxicity were observed (American Cyanamid Company 1959).