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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: study data do not give sufficient experimental details; in addition, it is ambigous if the test design used is suitable for testing the acute inhalation toxicity

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958

Materials and methods

Principles of method if other than guideline:
other: acute inhalation toxicity
GLP compliance:
no
Test type:
other: acute inhalation toxicity

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
other: different species: rabbit, guinea pig, rat, mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Duration of exposure:
4 h
Concentrations:
4 g of the test substance was heated up to 180°C in a 400 l room
No. of animals per sex per dose:
1 rabbit, 1 guinea pig, 2 rats, 4 mice
Control animals:
not specified

Results and discussion

Any other information on results incl. tables

Results:

All animals showed effects on respiration (exacerbate breathing) during exposure

Mortality: 1/1 guinea pig; 0/1 rabbit, 0/2 rats; 0/4 mice

After exposure the animals showed breathing difficulties , which were reversible

Applicant's summary and conclusion