Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: repeated dose
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary literature available

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Environmental health control for the rubber industry, part II
Author:
McCormick, W.E.:
Year:
1972
Bibliographic source:
Rubber Chemistry and Technology 45, 627-637
Reference Type:
study report
Title:
Unnamed
Year:
1959

Materials and methods

Principles of method if other than guideline:
other: repeated dose toxicity
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
migrated data set

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: Wesson oil
Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
migrated data set
Frequency of treatment:
migrated data set
Doses / concentrations
Remarks:
Doses / Concentrations:
400 mg/kg bw/d
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Post-exposure period: no

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
no signs of systemic toxicity, severe degrees of skin irritation

Applicant's summary and conclusion

Executive summary:

Repeated dose application on rabbit skins showed no signs of systemic toxicity, but severe degrees of skin irritation (McCormick 1972).