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EC number: 242-582-0
CAS number: 18794-84-8
NOAEL rat (in mg/Kg bw/day) into dermal NOAEL rat (in mg/Kg bw/day) by
correcting for differences in absorption between routes as well as for
differences in dermal absorption between rats and humans.
= oral NOAEL x
(ABSoral-rat/ ABSdermal-rat) x (ABSdermal-rat/ABSdermal-human)
= 1000 mg/Kg
bw/day x (ABSoral-rat/ ABSdermal-human)
= 1000 mg/Kg
bw/day x (1/1)
dermal NOAEL = 1000 mg/Kg bw/day
Dermal absorption assumed not be higher than oral absorption, therefore
no default factor (i.e. factor 1) introduced when performing
oral-to-dermal extrapolation (ECHA Guidance on information requirements
and chemical safety assessment Chapter R.8: Characterisation of dose
[concentration]-response for human health, Version 2.1, November 2012).
necessary (assuming 100% absorption for both routes in both species)
NOAEL= 1000 mg/Kg bw/day
absorption for both routes in both species assumed (ECHA Guidance on
information requirements and chemical safety assessment Chapter R.8:
Characterisation of dose [concentration]-response for human health,
Version 2.1, November 2012).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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