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Ecotoxicological information

Long-term toxicity to fish

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Description of key information

No chronic aquatic toxicity data are available for farnesene. Based on a read-across study with a structural analogue - farnesane, the NOEC for chronic toxicity of farnesene to fish is predicted to be greater than the limit of water solubility (11 μg/L).

Key value for chemical safety assessment

Additional information

There are no chronic data on the aquatic toxicity of farnesene. In a read-across chronic 'early life' stage study in fathead minnows with farnesane, the NOEC was 66 μg a.i./L. The LOEC and the Maximum Acceptable Toxicant Concentration was estimated to be >66 μg a.i./L, the highest concentration tested. The measured concentrations were greater than the known water solubility of farnesane (0.25 μg/L). Nevertheless, the lack of effects in this study confirm no toxicity at the limit of water solubility.

Based on read-across to the analogue farnesane, it is predicted that farnesene will not cause toxicity to fish at the limit of solubility (11μg/L). Justification for the use of read-across data can be found in section 13 of the dossier.