Registration Dossier
Registration Dossier
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EC number: 233-038-3 | CAS number: 10025-73-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: summarized in a well-known publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding toxicity data: List VII
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A., Nycum J.S.
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J., 1969, 30:5, 470-476
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Chromium trinitrate
- EC Number:
- 236-921-1
- EC Name:
- Chromium trinitrate
- Cas Number:
- 13548-38-4
- Test material form:
- other: nonahydrate
- Details on test material:
- No further information on the test material is available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: inhouse
- Age at study initiation: 4 - 5 weeks
- Weight at study initiation: 90 - 120g
- Fasting period before study: not fasted
- Diet: Rockland rat diet
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other:
- Details on oral exposure:
- applied as aqueous solution of 0.2 gram/mL
- Doses:
- Logarithmic series, differing by a factor of 2
- No. of animals per sex per dose:
- 5 animals per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- LD50 and fiducial range estimated by the method described by Thomson (Thomson, W.R., Bacteriol. Rev., 1947, 11, 115) and Weil (Weil, C.S., Biometrics, 1952, 8, 249).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 250 mg/kg bw
- Based on:
- test mat.
- Remarks:
- chromium trinitrate nonahydrate
- 95% CL:
- >= 2 110 - <= 4 990
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- It is summarized that LD50 of chroniumnitrate nonahydrate by oral gavage application is 3250 mg/kg bw.
- Executive summary:
The work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, these results (LD50 (oral, rat) = 3250 mg/kg bw) are deemed reliable.
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