Registration Dossier
Registration Dossier
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EC number: 233-038-3 | CAS number: 10025-73-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Chromium(III) compounds showed low systemic availability and only low potential for bioaccumulation. Typical oral absorption rates were reported in the range of 0.2 - 4%. Similar values are reported for dermal absorption and inhalative absorption. Anticipating higher absorption rates for soluble chromium(III) compounds, an absorption rate of 10% for oral, dermal and inhalative exposure is assumed as worst case assumption for chromium trichloride.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 10
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 10
Additional information
Although the behaviour of chromium in biological tissue varies according to degree of water solubility, in general, trivalent chromium compounds (in contrast to hexavalent chromium) are poorly absorbed and taken up by cells when not organically complexed.
Up to 1% of chromium III is absorbed from the normal diet, inhaled chromium III uptake is a very slow process, and chromium III compounds were not shown to be absorbed across the skin into systemic circulation. The prominent tissues for chromium distribution are the liver, kidneys and spleen as well as bone and the remaining carcass (muscle, skin and hair). There is no clear evidence to show the valency of trivalent chromium changes during metabolism and absorbed chromium III is mainly excreted in the urine and to a lesser extent in the faeces.
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