Registration Dossier

Administrative data

Endpoint:
other distribution data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reliable test data fromstability trials performed prior to GLP-compliant, OECD guideline test of toxicity to aquatic invertebrates and algae

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
2007
Report Date:
2007
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report Date:
2007

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Stability tests measuring test substance concentrations in water at 0h and then after 48 or 96h, comparing open and closed vessels
GLP compliance:
yes
Type of study:
other: Stability trials prior to aquatic toxicity tests
Media:
water - air

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: clear,colourless liquid
Details on test material:
Batch OD61002001

Results and discussion

Any other information on results incl. tables

Stability trials: analytical findings

 

Test duration

48h (prior to Daphnia test)

96h (prior to algal test)

Nominal initial concentration

(mg/l)

100

320

1000

10

100

1000

Measured initial concentration (mg/l)

95.1

302

955

11.2

107

1070

Final concentrations (% of 0h value)

Sealed vessel, light

97

89

99

0 (<LOQ)

28

94

Sealed vessel, dark

94

94

97

0 (<LOQ)

24

94

Open vessel, dark

29

Not determined

20

0 (<LOQ)

Not determined

0 (<LOQ)

Results in shaded boxes show rapid loss of test substance from open vessels, not seen in sealed replicate vessels

Applicant's summary and conclusion

Conclusions:
In these tests performed at ambient laboratory temperature, GC analysis of aqueous solutions showed 65-77% loss of test substance via volatilisation from water over 48h at 95-955 mg/l, and total or near-total total loss over 96h at 1070 mg/l.