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EC number: 200-068-3
CAS number: 50-85-1
Skin irritation study of test chemical
Methylbenzoate (CAS No: 93-58-3)was carried out in 14male New Zealand
albino rabbitsto observe its irritation potential.
Undiluted methyl benzoate was applied
to the clipped dorsum (0.5mL) and external surface of the outer ear
male New Zealand albino rabbits The
rabbits were observed for 6 days for signs of irritation.On the dorsum
there were marked cellular reactions and dermal edema beginning on day 2
followed by dermal hemorrhage, desquamated crust, and thickening of the
malpighian stratum beginning on day 5 were observed and on the inner
ear, there was slight hyperkeratosis on day 6.
Since the test chemical was rated as
grade 1,Methylbenzoate (CAS No: 93-58-3) was considered to be irritating
to the clipped dorsum and external surface of the outer ear of male new
Zealand albino rabbits.
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