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EC number: 200-068-3
CAS number: 50-85-1
Table 1: Physchem Parameters and
Primary Irritation Scores
Name of the test chemical
*= Hansch and Leo, 1979, -=not
evaluated due to corneal opacity
Figures in parenthesis indicate the
days of recovery.
The primary eye irritation potential
of 4-methylsalicylic acid was evaluated according to Draize method.
3 female Japanese White rabbits
(2.0-2.2 kg) were used for the study. The chemical (if solid= 100 mg, if
liquid = 0.1ml) was instilled into the conjunctival sac of the left
eye.Right eye (untreated eye) served as blank control.The eyes were
examined and the grade of ocular lesions was recorded at 1, 24, 48, 72,
96 hours and 7, 14, 21 days after administration of test
chemical.Corneal opacity, erythema, chemosis, secreta and iritis were
recorded and classified under Draize method (Draize et.al, 1944)
The sum of values, recorded for
cornea, conjunctiva and iris was divided by the number of observation
times and the average scores (Draize scores) were used as grades of
ocular irritation potential of the chemical
The maximum value of Draize score are
as follows: Cornea =80, Conjunctiva = 20 and Iris = 5
The average Draize scores after 21
days were as follows:CORNEA = 33.9/80, iris = 0.6, conjunctiva = 5.1.
4-methylsalicylic acid caused moderate
eye irritation recovering within 21 days of treatment.
Hence,4-methylsalicylic acid can be
considered irritating to eyes.
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