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EC number: 200-068-3
CAS number: 50-85-1
Dose:2000 mg/ kg
Body Weight (gram)
Body Weight Change (%)
Hour(s) - Day 0
1 = Normal
Dose:2000 mg/kg body
Days of Observation (0 to 14)
No mortality and morbidity
mg/kg body weight
Body Weight Changes (%)
Standard deviation, n = Number of animals
mg/kg body weight Mode
of Death:Terminal Sacrifice
No abnormality detected
Acute dermal Toxicity Study of Sodium
salicylate in Rats was performed as per OECD No. 402 (Acute Dermal
Toxicity) . Five male and five female healthy young adult rats were
randomly selected and used for conducting acute dermal toxicity study.
Ratsfree from injury and irritation of skin were selected for the study.
Twenty four hours prior to dermal application of test item,
approximately 10% of body surface area of each rat was clipped. A limit
dose of 2000 mg/ kg body weight of test item moistened with 0.2 ml
distilled water was applied directly on the intact skin of clipped area
of rats; the porous gauze dressing was put on to the intact skin of
clipped area.This porous gauze dressing was covered with a
non-irritating tape.After the 24-hour application period, the dressings
were removed and theskin was gently wiped with distilled water.The skin
reactions were assessed. All animals were observed for clinical signs at
approximately 1, 2, 3 and 4 hours after treatment on day 0 and once
daily during test days 1‑14. Mortality was recorded after application on
test day 0 and twice daily during days 1-14 (at least once on the day of
sacrifice). Local signs / Skin reactions were observed daily from test
days 1-14 (in common with clinical signs). Body weights were recorded
on day 0 (prior to application) and on day 7 and 14. All animals were
necropsied and examined macroscopically. No mortality was observed in
any animal till the end of the experimental period. All the animals
shows normal clinical signs, mean body weight was observed with gain on
day 7 and 14. Gross pathological observation of all terminally
sacrificed animals did not show any pathological abnormality.Thus, The
LD50 value was considered to be >2000 mg/kg bw,when male and female
wistar rats were occlusively treated with Sodium salicylate (54-21-7)
by dermal application following 14 days of observation period according
to OECD Guideline 402 (Acute Dermal Toxicity).
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