Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted according to current accepted guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report Date:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
no
Type of method:
thermal analysis

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Manganese sulfate (note that the batch number is the same as used in the GLP water solubility study, which stated the substance name as manganese sulphate monohydrate, with a CoA in that report confirming this)
- Substance type: Pink crystalline solid
- Physical state: Solid
- Lot/batch No.: 08729
- Storage condition of test material: Room temperature in the dark.

Results and discussion

Melting / freezing point
Melting / freezing pt.:
> 723 K
Remarks on result:
other: ± 0.5

Any other information on results incl. tables

As there were no significant thermal events, it was determined that no changes in the physical state of the test material occurred over the range of 25 to 450 °C.

During both determinations, an endotherm was displayed by both Thermograms. These are tabulated in table 3 (see below).

 

Table 3: Thermographic Data from Determinations 1 and 2

 

Determination

Thermal Event

Interpretation

Temperature

°C

K

1 (Air, Static)

Endotherm

Loss of water (water of crystallisation)

~280

~553

2 (Nitrogen)

Endotherm

Loss of water (water of crystallisation)

~280

~553

 

Applicant's summary and conclusion

Conclusions:
The melting temperature of manganese sulphate was determined to be > 723 ± 0.5 K. The endotherms observed in both thermograms were attributable to the loss of water from the monohydrate. The final mpt will be for the anhydrous substance, as registered.