Registration Dossier

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Manganese induced hepatic lesions in carbon tetrachloride pretreated rats
Author:
Chandra SV and Saxena dK
Year:
1975
Bibliographic source:
Exp Path Bd, 10: 285-288

Materials and methods

Principles of method if other than guideline:
Manganese sulphate was administered intraperitoneally daily for 30 days in carbon tetrachloride pretreated rats.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
MnSO4.4H2O

Results and discussion

Any other information on results incl. tables

Histological and histochemical studies in liver tissue revealed extensive damage to hepatic parenchyma in these rats as compared to lesions produced by manganese sulphate alone.

Applicant's summary and conclusion

Conclusions:
These findings suggest that workers, with liver dysfunction engaged in the manganese industry may be more susceptible to the toxic effects of this metal.