Registration Dossier
Registration Dossier
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EC number: 231-786-5 | CAS number: 7727-54-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983-03-02 to 1983-03-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- NA
- GLP compliance:
- no
Test material
- Reference substance name:
- Diammonium peroxodisulphate
- EC Number:
- 231-786-5
- EC Name:
- Diammonium peroxodisulphate
- Cas Number:
- 7727-54-0
- Molecular formula:
- H3N.1/2H2O8S2
- IUPAC Name:
- diammonium peroxodisulphate
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino - White Russian
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: 4-5 months
- Weight at study initiation: 2.0 - 2.2 kg
- Housing: individually in stainless steel cages
- Diet (e.g. ad libitum): standardised test animal feed, Altromin
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 °C ± 1°C
- Humidity (%): 50 - 60 %
- Photoperiod (hrs dark / hrs light): 12 hours light/ 12 hours dark
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 0.5 g of the test substance.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48, 72 h
- Number of animals:
- 3
- Details on study design:
- NA
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritant / corrosive response data:
- No systemic-toxic effects occurred after treatment with the test material. All animals remained healthy throughout the study.
- Other effects:
- NA
Any other information on results incl. tables
No remarks
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under conditions of the study, diammonium Persulfate revealed no skin irritating properties.
- Executive summary:
Diammonium persulfate was applied in a single dose of 0.5 g diammonium persulfate to intact skin of albino rabbits. One hour after the end of the exposure period the three rabbits had slight erythema which disappeared at the time of the study observation time points after 24 and 48 hours. None of the animals reach an average erythema or edema score equal or above 2. The highest score (edema score) was 0.33 obtained in one of the three rabbits. Under the conditions of the study diammonium persulfate was not considered irritating to skin. Additionally, no systemic-toxic effects occured after treatment with the test material. All animals remained healthy throughout the study.
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