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EC number: 231-786-5 | CAS number: 7727-54-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001-05-21 to 2001-10-18
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- August 1998
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 24 February 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- January 1993
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Diammonium peroxodisulphate
- EC Number:
- 231-786-5
- EC Name:
- Diammonium peroxodisulphate
- Cas Number:
- 7727-54-0
- Molecular formula:
- H3N.1/2H2O8S2
- IUPAC Name:
- diammonium peroxodisulphate
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: 8 - 12 weeks
- Weight at study initiation: Males. 215 - 266 g; Females: 151 - 188 g
- Fasting period before study: overnight prior to dosing
- Housing: individually in stainless steel suspended cages with DACB indirect bedding
- Diet: Purina Rodent Chow 5001 (pellets) ad libitum
- Water: fresh tap water ad libitum
- Acclimation period: minimum of 5 calendar days
ENVIRONMENTAL CONDITIONS
- Temperature: 19.4 - 24.4 °C
- Humidity: 41 - 68 % R.H.
- Air changes (per hr): not stated
- Photoperiod: 12 hours dark/12 hours light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test material could not be administered undiluted because it was a solid. The highest possible concentration of the test material that could be drawn through a gavage needle was a 50 % (w/v) concentration in tap water; the concentration used in this study was 25 % because using 50 % would result in dose volumes which were too low to administer. The test material was mixed with tap water and then mixed prior to and during dosing on a magnetic stirrer plate. The test material was introduced directly into the stomach of each animal via oral gavage.
- Doses:
- Males: 300, 500, 660, 750 mg/kg bw
Females: 300, 660, 750 mg/kg bw - No. of animals per sex per dose:
- 5 males/5 females per dose
- Control animals:
- not specified
- Details on study design:
- The rats were fasted overnight prior to dosing. The test material was introduced directly into the stomach of each animal via oral gavage. The animals were dosed at approximately 8:30 a.m.
Clinical signs:
The animals were observed for mortality 0.5, 1, 2, 3, 4, and 6 hours following dosing, and daily thereafter for fourteen days.
Body weights:
Body weights were recorded on days 0, 7 and 14 and prior to necropsy.
Necropsy:
Gross necropsies were performed on all animals upon study completion on day 14 following sacrifice via carbon dioxide inhalation. Any animals not surviving to termination were also necropsied. - Statistics:
- The LD50 calculations were performed using a modified Logit-Linear Regression Program written by Jim Gibbons, Texas Instruments Calculator Products Division.
Results and discussion
- Preliminary study:
- No data
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 742 mg/kg bw
- 95% CL:
- >= 237 - <= 1 247
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 700 mg/kg bw
- 95% CL:
- >= 502 - <= 898
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- 300 mg/kg bw
- Mortality:
- All deaths occurred within the first three days post dosing. The mortality data are summarized in sect. "Remarks on results incl. tables".
- Clinical signs:
- other: The predominant clinical signs were abdominal gripping, abdominogenital staining, ataxia, anorexia, chromodacryorrhea, chromorhinorrhea, diarrhea, decreased feces, decreased locomotion, dehydration, hypothermia, lacrimation, no feces, oral discharge, trem
- Gross pathology:
- No gross lesions were found during necropsy.
- Other findings:
- None
Any other information on results incl. tables
Table 1: Mortality data:
Male |
Female |
||
Dosage Level (mg/kg) |
No. Dead/ No. Dosed |
Dosage Level (mg/kg) |
No. Dead/ No. Dosed |
750 |
3 / 5 |
750 |
3 / 5 |
660 |
0 / 5 |
660 |
2 / 5 |
500 |
2 / 5 |
500 |
1 / 5 |
300 |
0 / 5 |
|
|
The LD50 values in mg/kg and the corresponding 95 % confidence limits are as follows:
Male: 742 (237 - 1247);
Female: 700 (502 - 898);
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 and LD0 were determined to be 742 mg/kg bw and 300 mg/kg bw, respectively in male rats and LD50 of 700 mg/kg bw in female rats.
- Executive summary:
Diammonium persulfate was tested for acute oral toxicity in the rat in a study according to EPA guideline 870.1100, OECD guideline 401 and EU method B.1. The oral LD50 and LD0 were determined to be 742 mg/kg bw and 300 mg/kg bw, respectively in male rats and LD50 of 700 mg/kg bw in female rats. Therefore, the test substance was considered slightly toxic by oral administration to rat.
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