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EC number: 203-002-1
CAS number: 102-06-7
In the MITI list (1987), DPG (1,3 -diphenylguanidine) is
described as a substance with at most a slight accumulation potential in
biological material. The measured log Kow value comes to reinforce this
assumption. Considering these results we can make the assumption that
DPG is characterized by a low potential of adsorption. That is the
reason why we propose to not perform a test. On the top of that, an
oldest study already exists, nevertheless very little information are
available on this data in order to challenge its validity. Effectively,
a study on the bioaccumulation of DPG, following test regulations
similar to OECD 305C (1981), exising Cyprinus carpio for 6 weeks
in a flow through system (0.2 - 0.8 ml/min; 25 +/-2°C; O2 content: 6 -8
mg/l; solubilizer was not specified), permitted to estimate a BCF of <2
and <20 at exposure concentration of 0.1 and 0.01 mg/l respectively. The
substance concentration in the test medium was analyzed twice a week
(CITI, 1992). As a consequence, this study is used as a supporting data
in order to confort the waiving proposal.
Based upon these results and on the log Kow value (=2.42),
it can be assumed that DPG is characterised by a low potential of
bioaccumulation in aquatic organisms.
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