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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Etude expérimentale des effets physiologiques de la diphénylguanidine
Author:
Valade P, Delga J et Salle J
Year:
1949
Bibliographic source:
Comptes Rendus Soc. Biol. 143, 815-817
Reference Type:
secondary source
Title:
N,N'-Diphenylguanindine
Author:
Bayer E.
Year:
1992
Bibliographic source:
BUA Report 96 (august 1992). GDCh- Advisory Committee on existing chemicals of environmental relevance.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No detail available
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-diphenylguanidine
EC Number:
203-002-1
EC Name:
1,3-diphenylguanidine
Cas Number:
102-06-7
Molecular formula:
C13H13N3
IUPAC Name:
1,3-diphenylguanidine
Details on test material:
No data

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: no data
Details on inhalation exposure:
For inhalation, animals (not precised) were exposed in inhalation chamber during 30 min.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
30 min
Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no
Statistics:
no data

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
>= 500 mg/m³ air (nominal)
Exp. duration:
30 min
Mortality:
no data
Clinical signs:
other: At 500 mg/m3, after 30 min of exposition, animals showed a slightly hypnotic effect.
Body weight:
no data
Gross pathology:
no data
Other findings:
no

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met