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EC number: 201-188-9
CAS number: 79-24-3
The acute oral LD50 in rabbits was slightly lower than for rats, 625 and
>/= 1000 mg/kg, respectively. The dermal LD50 was >2000 mg/kg in
rabbits. The acute inhalation LC50 in rats is considered to be 6025
Table 1 Acute Oral Toxicity of P-1355 in Rats
Gross Pathological Observations*
All organs normal
#8, 9 lung infection
#2 lung infection
#6 lung infection
4/1, 5/2, 1/3
#10 lung infection
#2, 3, 4, 7, 8 lung infection
#1, 2, 4, 5 lung infection
#1 lung infection
*On surviving animals
The acute oral toxicity of nitroethane was examined. The acute oral.LD50 of nitroethane (P-1355) in male rats was 1428 (1232-1657) mg/kg and in the female rats was 1083 (991-1167) mg/kg.
Experiment 1: Rats were exposed to 13,000 ppm nitroethane for several
hours. The rats died 6 -7 hours during the inhalation exposure. The
methemoglobin level of 2.8% was lower than that recorded for the
nitropropanes, either 1 -NP or 2 -NP. Similarly with nitrite ion
concentration. NE was found in the liver (0.8 mg) as well as in the
lungs (0.1 ml).
Experiment 2: Animals placed in an atmosphere of 2200 ppm (6.8 mg/L) of
nitroethane survived numerous 6-hour inhalation sessions. Nonmetabolized
nitroethane in the liver was 0.1 mg/100 g. Since no noticeable effects
were observed in rats exposed to 2200 ppm, groups of rats were exposed
to lower concentrations for longer periods of time.
Experiment 3: Groups of rats were exposed to 550 ppm (1.55 mg/L) for 6
hours/day for 12 exposures. There was no methemoglobin noted in the
blood and only traces of nitrites in the organs.
Experiment 4: Groups of rats were exposed to 200 ppm (0.625 mg/L) for 6
hours/day for 12 exposures. Similar to the results in experiment 3,
there was no methemoglobin noted in the blood and only traces of
nitrites in the organs.
Table 1 Effects following nitroethane exposure via inhalation
The acute toxicity of nitroethane was examined following a single
exposure to 13'000 ppm and repeated exposure to lower concentrations.
Under the conditions of this study, the LC100 is 13'000 ppm following a
six hour exposure to nitroethane. All rats exposed to 2200 ppm of
nitroethane for 6 hours/day for 5 days survived (LC0). This study was
conducted before guidelines and GLP, but sufficient data is available
for interpretation of results. Normalizing the LC0 value for a 4
hour exposure, this is equivalent to a LC50 of 6025 ppm/4 hr (2200*301/2/
41/2). According to the CLP/GHS legislation,
nitroethane can be classified as Category 4 for acute toxicity via the
No additional information available.
The dermal toxicity of nitroethane was examined. All rabbits survived 24 hour exposure to 2000 mg/kg nitroethane as well as a 14 day observation period.
The acute oral toxicity of nitroethane was examined in rats. In
the most reliable study, the acute oral LD50 ranged from approximately
1428 mg/kg in male rats and 1083 mg/kg in female rats. In
a dermal toxicity study of nitroethane all rabbits survived a 24 hour
exposure to 2000 mg/kg nitroethane as well as a 14 day observation
period. The acute toxicity of nitroethane to rats was examined following
a single exposure to 13,000 ppm and repeated exposure to lower
concentrations. Under the conditions of this study, the acute LC50 is
considered to be 6025 ppm.
The acute oral LD50 from the key study is 1083 and 1428 mg/kg in female
and male rats, respectively. Therefore, nitroethane is classified as
category 4 under GHS. The acute inhalation LC50 is considered to be 6025
ppm (19'882 mg/m3) and, therefore, nitroethane is classified as category
4 under CLP/GHS. The dermal LD50 is greater than 2000 mg/kg and,
therefore, nitroethane is not classifiable for acute dermal toxicity
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