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EC number: 201-188-9
CAS number: 79-24-3
The dose levels were chosen based on a 14-day study with 10, 50, 150 and 250 mg/kg test material. All animals treated with 250 mg/kg and one animal treated with 150 mg/kg were killed in extremis. No effects were noted at 10 mg/kg. A detailed justification for setting the NOAEL (actually a NOEL) at 30 mg/kg was provided by the investigators. Effects considered to be related to treatment with 100 mg/kg/day were hunched posture, lethargy, ataxia and death. Effects considered possibly related to treatment with 100 mg/kg/day were reduced body weight gain and increased brain weight. The increase in the absolute brain weight of females treated with 30 mg/kg/day was not considered to be biologically significant since an increase in the relative weight was not observed. Changes in clincial chemistries, hematologies, urinalysis and weights of organs other than the brain were not considered to be related to treatment since there were no corresponding morphologic changes and/or the changes were not dose-dependent.
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