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EC number: 201-188-9 | CAS number: 79-24-3
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: clinical case reports
- Adequacy of study:
- supporting study
- Study period:
- circa 1982 - 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Case reports of childred accidentally ingesting nitroethane
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Nitroethane poisoning from an artificial fingernail remover.
- Author:
- Hornfeldt, C.S. and Rabe, W.H.
- Year:
- 1 994
- Bibliographic source:
- Clin Toxicol 32(3): 321-324.
- Reference Type:
- publication
- Title:
- Rebound severe methemoglobinemia from ingestion of a nitroethane artificial-fingernail remover
- Author:
- Osterhoudt, K.C., Wiley, C.C., Dudley, R., Sheen, S. and Henretig, F.M.
- Year:
- 1 995
- Bibliographic source:
- J Pediatrics 126: 819-821.
- Reference Type:
- publication
- Title:
- Prolonged formation of methemoglobin following nitroethane ingestion
- Author:
- Shepherd, G., Grover, J. and Klein-Schwartz, W.
- Year:
- 1 998
- Bibliographic source:
- Clin Toxicol 36: 613-616
- Reference Type:
- publication
- Title:
- Severe Methemogolbinemia following Nitroethane Ingestion
- Author:
- Wells, S.R. and Anderson, D.A.
- Year:
- 1 996
- Bibliographic source:
- Clinical Toxicology, 34:5, 553 - 636 Poster Session A
Materials and methods
- Study type:
- poisoning incident
- Principles of method if other than guideline:
- Case reports of accidental poisoning
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Nitroethane-containing artificial nail removers. At least one case report cited the test material as 100% nitroethane.
Constituent 1
Method
- Subjects:
- 5 children who accidentally ingested artificial nail remover.
- Route of exposure:
- oral
- Reason of exposure:
- accidental
- Exposure assessment:
- estimated
Results and discussion
- Clinical signs:
- In each instance, cyanosis and methemoglobinemia occurred 5-10 hours after exposure.
Any other information on results incl. tables
The clinical signs resolved after treatment with methylene blue. The delayed onset of methemoglobinemia suggests that a metabolite was responsible. Nitrites are acknowledged as formers of methemoglobin.
Applicant's summary and conclusion
- Conclusions:
- Cyanosis and methemoglobinemia occurred 5-10 hours after exposure, which resolved after treatment with methylene blue. The delayed onset of methemoglobinemia suggests that a metabolite was responsible.
- Executive summary:
Five clinical cases were reported of children accidentally ingesting several drops to 90 ml of artificial fingernail removers containing nitroethane.The cases occurred in children aged 1-3, who ingested anywhere from "a few drops" to 90 ml of the products. In each instance, cyanosis and methemoglobinemia occurred 5-10 hours after exposure, which resolved after treatment with methylene blue. The delayed onset of methemoglobinemia suggests that a metabolite was responsible.
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