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EC number: 201-188-9
CAS number: 79-24-3
Experiment 1: Rats were exposed to 13,000 ppm nitroethane for several
hours. The rats died 6 -7 hours during the inhalation exposure. The
methemoglobin level of 2.8% was lower than that recorded for the
nitropropanes, either 1 -NP or 2 -NP. Similarly with nitrite ion
concentration. NE was found in the liver (0.8 mg) as well as in the
lungs (0.1 ml).
Experiment 2: Animals placed in an atmosphere of 2200 ppm (6.8 mg/L) of
nitroethane survived numerous 6-hour inhalation sessions. Nonmetabolized
nitroethane in the liver was 0.1 mg/100 g. Since no noticeable effects
were observed in rats exposed to 2200 ppm, groups of rats were exposed
to lower concentrations for longer periods of time.
Experiment 3: Groups of rats were exposed to 550 ppm (1.55 mg/L) for 6
hours/day for 12 exposures. There was no methemoglobin noted in the
blood and only traces of nitrites in the organs.
Experiment 4: Groups of rats were exposed to 200 ppm (0.625 mg/L) for 6
hours/day for 12 exposures. Similar to the results in experiment 3,
there was no methemoglobin noted in the blood and only traces of
nitrites in the organs.
Table 1 Effects following nitroethane exposure via inhalation
The acute toxicity of nitroethane was examined following a single
exposure to 13'000 ppm and repeated exposure to lower concentrations.
Under the conditions of this study, the LC100 is 13'000 ppm following a
six hour exposure to nitroethane. All rats exposed to 2200 ppm of
nitroethane for 6 hours/day for 5 days survived (LC0). This study was
conducted before guidelines and GLP, but sufficient data is available
for interpretation of results. Normalizing the LC0 value for a 4
hour exposure, this is equivalent to a LC50 of 6025 ppm/4 hr (2200*301/2/
41/2). According to the CLP/GHS legislation,
nitroethane can be classified as Category 4 for acute toxicity via the
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