Ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1982

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test was performed in principle as described in OECD test guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at 20°C. Young adult laboratory rats, 3 males and 3 females per experiment, were exposed to the vapors generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 7 h. Since the substance is UV light sensitive, the experiment was performed in the dark. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure. Group-wise documentation of clinical signs was performed over a 14 day study period.

GLP compliance:

no

Test type:

other: inhalation risk test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate

EC Number:

282-810-6

EC Name:

Ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate

Cas Number:

84434-11-7

Molecular formula:

C18H21O3P

IUPAC Name:

ethyl phenyl(2,4,6-trimethylbenzoyl)phosphinate

Details on test material:

- Name of test material (as cited in study report): Initiator 654
- Physical state: yellow liquid
- Analytical purity: > 97%
- Expiration date of the lot/batch: Feb. 1983

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Three animals per cage; type: wire cage (Becker, D III)
Identification of animals: Toe amputation
Age at start of study: 8 - 9 weeks
Acclimatization period: At least 5 days
Weight of animals at start of study: males 293 g, females 233 g (on average)
Animal housing / room temperature: 22 ± 2°C
Relative humidity: 55 ± 5%
Illumination day/night rhythm: 12 h/12 h (6.00 - 18.00 hours light, 18.00 - 6.00 hours dark)
The animals received SSNIFF R complete diet for rats and mice, supplied by SSNIFF Versuchstierdiäten GmbH, Soest, FRG, in the form of pellets ad libitum and about 250 ml/cage tap water daily.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Remarks on duration:

14 day observation period

Concentrations:

no substance loss could be determined over the course of the experiment. Based on the saturated vapour pressure, the saturated vapour concentration can be calculated to be 2.7e-5 mg/l.

No. of animals per sex per dose:

6 (3 per sex each in 2 independent experiments)

Control animals:

no

Details on study design:

Clinical signs and mortality of the animals were recorded each workday and daily, respectively. The animals that died or those sacrificed with carbon dioxide at the end of the post-exposure observation period were subjected to a gross-pathological examination.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

>= 0 mg/L air

Based on:

other: calculated (equals saturated vapour concentration)

Exp. duration:

7 h

Mortality:

None

Clinical signs:

other: No abnormalities detected.

Gross pathology:

No abnormalities detected.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification