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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Version / remarks:
(Directive 92/69/EEC, C.7)
GLP compliance:
yes (incl. certificate)
Radiolabelling:
no
Analytical monitoring:
yes
Buffers:
Demineralized water (Milli-Q system)
buffer pH 4.0 (Bemd Kraft GmbH ; citric acid, sodium chloride, sodium hydroxide)
buffer pH 7.0 (Bernd Kraft GmbH ; phosphate mixture)
buffer pH 9.0 (Riedel de Haën; sodium borate, hydrochloric acid)
acetonitrile (Riedel-de Haën)
buffer pH = 4 (GKA reference material A 21491041LC_824)
buffer pH = 10 (GKA reference material A 22571031LC_824) for testing of pH meter.
Transformation products:
not measured
pH:
4
Temp.:
70 °C
DT50:
158 h
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
30 °C
DT50:
114 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
50 °C
DT50:
< 2.4 h
Type:
(pseudo-)first order (= half-life)
Validity criteria fulfilled:
not specified
Conclusions:
The substance was found to be stable at pH 4 and 7, respectively, but hydrolyses at pH 9 with a half-life below 2.4 hours at 50°C.

Description of key information

The study was conducted to recognised testing guidelines, and with GLP certification.

Key value for chemical safety assessment

Half-life for hydrolysis:
158 h
at the temperature of:
70 °C

Additional information