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EC number: 202-433-2 | CAS number: 95-57-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
According to the standard information requirements defined in Regulation 2006/1907, Annex VII, no data on reproductive toxicity are required. However, publically available information on reproductive toxicity of 2-chlorophenol is summarized below. As the available sources do not provide sufficient data for hazard evaluation, no key information is defined.
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Limited data on reproductive toxicity of 2-chlorophenol is available (as cited in ATSDR, 2013).
2-chlorophenol was applied to female Sprague Dawley rats via drinking water beginning at weaning and extending through, rearing, mating and parturition (Exon and Koller, 1985, as cited in ATSRD, 2013). Concentrations ranging from 5 - 50 mg/kg bw/day were applied. The total exposure duration was approximately 13 weeks. A marginal decrease (p<0.10) in litter size at 30 mg/kg bw/day is reported. No significant reproductive effects were observed at 5 mg/kg bw/day.
References not included in IUCLID
Agency for Toxic Substances and Disease Registry, Division of Toxicology and Human Health Sciences (ATSDR), 2013. Addendum to the toxicological profile for chlorophenols. Atlanta, GA 30333
Exon and Koller, 1985 (as cited in ATSDR, 2013). Toxicity of 2-chlorophenol, 2,4-dichlorophenol and 2,4,6-trichlorophenol, In: Jolley RL, ed. Water Chlorination: Chemistry, environmental impact and health effects. Volume 5. Fifth Conference on Water Chlorination: Environmental Impactand Health Effects, Williamsburg, VA, June 1984, 307-330.
Effects on developmental toxicity
Description of key information
According to the standard information requirements defined in Regulation 2006/1907, Annex VII, no data on (prenatal) developmental toxicity are required. However, publically available information on developmental toxicity of 2-chlorophenol is summarized below. As the available sources do not provide sufficient data for hazard evaluation, no key information is defined.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Limited data on developmental toxicity of 2-chlorophenol is available (as cited in ATSDR, 2013).
Pregnant rats were exposed to 2-chlorophenol at doses up to 50 mg/kg bw/day via the drinking water throughout gestation and up to 91 days post partum. No significant changes in offspring body or liver weights were observed in (Exon and Keller 1981, 1983, 1985, as cited in ATSDR, 2013). However, it has been shown that transplacental exposure to 2-chlorophenol can be feto- or embryotoxic at a high dose, resulting in a significant increase in the number of stillborn pups and decreased live litter size at 50 mg/kg bw/day (Exon and Koller 1982, 1985, as cited in ATSDR, 2013).
References not included in IUCLID
Agency for Toxic Substances and Disease Registry, Division of Toxicology and Human Health Sciences (ATSDR), 2013. Addendum to the toxicological profile for chlorophenols. Atlanta, GA 30333
Exon and Koller, 1981 (as cited in ATSDR, 2013). Alteration of transplacental carcinogenesis by chlorinated phenols. In: Jolley RL, Brungs WA, Cotruvo WA, et al., eds. Water Chlorination: Environmental impact and health effects, Volume 4, Book 2. Ann Arbor, MI: Ann Arbor Science, 1177-1188.
Exon and Koller, 1982 (as cited in ATSDR, 2013). Effects of transplacental exposure to chlorinated phenols. Environ Health Perspect 46:137-140.
Exon and Koller, 1983 (as cited in ATSDR, 2013). Effects of chlorinated phenols on immunity in rats. Int J Immunopharmacol 5(2):131-136.
Exon and Koller, 1985 (as cited in ATSDR, 2013). Toxicity of 2-chlorophenol, 2,4-dichlorophenol and 2,4,6-trichlorophenol, In: Jolley RL, ed. Water Chlorination: Chemistry, environmental impact and health effects. Volume 5. Fifth Conference on Water Chlorination: Environmental Impact and Health Effects, Williamsburg, VA, June 1984, 307-330.
Justification for classification or non-classification
Based on the available data, no final decision on classification for reproductive or developmental toxicity can be made. However, taking into consideration the harmonized classification, 2-chlorophenol is not expected to exhibit hazardous properties in regard to fertility or embryonic/fetal development.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.