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EC number: 202-433-2 | CAS number: 95-57-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 Jun - 18 Jul 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- Limited details on inhalation exposure given, no data on MMAD given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- as adopted 12 May 1981
- Deviations:
- yes
- Remarks:
- limited data on inhalation exposure given, no data MMAD given
- GLP compliance:
- yes
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- 2-chlorophenol
- EC Number:
- 202-433-2
- EC Name:
- 2-chlorophenol
- Cas Number:
- 95-57-8
- Molecular formula:
- C6H5ClO
- IUPAC Name:
- 2-chlorophenol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Hoechst Celanese Corporation, batch 55312
- Expiration date of the lot/batch: 30 Dec 1991
- Purity test date: >99%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Stored at room temperature, in the original container, protected from light
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: The test material was used as supplied.
FORM AS APPLIED IN THE TEST (if different from that of starting material): For the low and mid dose group the test material was administered following vaporization. For the high dose group the test material was nebulized followed by filtration.
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: BRL, Biological Research Laboratories Ltd, CH-4414 Fuellinsdorf, Switzerland
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: males: 8 weeks; females 10 weeks
- Weight at study initiation: males: 180 - 192 g; females: 186 - 200 g
- Housing: in groups of five in Makrolon cages type 4 with softwood bedding
- Diet: pelleted standard Kliba 343 maintance diet, ad libitum
- Water: community tap water from Geneva, ad libitum
- Acclimation period: 4 to 9 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 15
- Humidity (%): 30 - 70
- Air changes (per hr): 10 - 15
- Photoperiod: 12/12
IN-LIFE DATES: From: 24 Jun 1991 To:18 Jul 1991
Administration / exposure
- Route of administration:
- other: Inhalation: For the low and mid dose group the test material was administered following vaporization. For the high dose group the test material was nebulized followed by filtration.
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Remark on MMAD/GSD:
- no data provided
- Details on inhalation exposure:
- no data provided
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0.089, 0.546 and 4.77 mg/L air (analytical concentration)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs and mortality were observed daily. Body weights were recorded prior to exposure and weekly thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weights - Statistics:
- A statistical analysis was not necessary/possible as no mortalities were noted.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 4.77 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortalities occurred during the study.
- Clinical signs:
- other: Restlessness was noted in all animals of the high dose group (4.77 mg/L) during exposure. This sign as well as hunched posture, ruffled fur and tachypnea (males only) were observed on test day 1 after exposure. Ruffled fur lasted until test day 2 in all h
- Body weight:
- No treatment-related effects on body weights were noted.
- Gross pathology:
- Isolated dark red or reddish foci were noted on one or several lung lobes of 2 males and 2 females, 4 males and 2 females of the low and mid dose group, respectively. No necropsy findings were noted in animals of the high dose group.
Any other information on results incl. tables
Table 1. Table for acute toxicity following inhalation
Target concentration |
Toxicological results* |
Duration of clinical signs |
Time of death |
Mortality (%) |
Males |
||||
0.089 |
0/0/5 |
--- |
--- |
0 |
0.546 |
0/0/5 |
--- |
--- |
0 |
4.77 |
0/5/5 |
Day 1-2 |
--- |
0 |
Females |
||||
0.089 |
0/0/5 |
--- |
--- |
0 |
0.546 |
0/0/5 |
--- |
--- |
0 |
4.77 |
0/5/5 |
Day 1-2 |
--- |
0 |
LC50 > 4.77 mg/L air |
* first number = number of dead animals |
||
second number = number of animals with clinical signs |
||
third number = number of animals used |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- 2-chlorophenol is classified as Acute Tox. 4, H332 according to Annex VI of Regulation (EC) No 1272/2008. Although the available data on acute toxicity following inhalation do not meet the classification criteria according to Regulation (EC) No 1272/2008, the registrant follows the harmonised classification.
- Conclusions:
- CLP: Acute toxicity, Cat. 4, H332
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