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Diss Factsheets
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EC number: 202-433-2 | CAS number: 95-57-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- (limited details on study design and results provided)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: A 14-day repeat dose toxicity study with 2-chlorophenol was performed including evaluation of sister chromatid exchanges. Groups of 12 male and female CD-1 mice were exposed to 2-chlorophenol at dose levels of 35, 69 and 175 mg/kg bw/day by oral gavage once daily for 14 consecutive days. Vehicle control animals received the vehicle, corn oil, only. In addition a treatment naive and a positive control group (cyclosphosphamide, 25 mg/kg bw) were included.
- Parameters analysed / observed: SCE (testes and bone marrow). - GLP compliance:
- not specified
- Type of assay:
- sister chromatid exchange assay
Test material
- Reference substance name:
- 2-chlorophenol
- EC Number:
- 202-433-2
- EC Name:
- 2-chlorophenol
- Cas Number:
- 95-57-8
- Molecular formula:
- C6H5ClO
- IUPAC Name:
- 2-chlorophenol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Assigned to test groups randomly: yes
- Housing: individually in plastic shoebox cage with hardwood sawdust bedding
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22° +/- 2°C
- Humidity (%): relative humidity 40-60%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- - Vehicle(s)/solvent(s) used: corn oil
- Amount of vehicle: 10 mL/kg bw
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS: prepared on day of administration
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- Once daily
- Post exposure period:
- none
Doses / concentrationsopen allclose all
- Dose / conc.:
- 35 mg/kg bw/day
- Remarks:
- Doses tested were 35, 69 and 175 mg/kg bw/day. All animals at 175 mg/kg bw/day died and could not be evaluated. Highest evaluated dose was 69 mg/kg bw/day.
- Dose / conc.:
- 69 mg/kg bw/day
- Remarks:
- Doses tested were 35, 69 and 175 mg/kg bw/day. All animals at 175 mg/kg bw/day died and could not be evaluated. Highest evaluated dose was 69 mg/kg bw/day.
- No. of animals per sex per dose:
- 12
- Control animals:
- yes, concurrent no treatment
- yes, concurrent vehicle
- other: yes, positive control
- Positive control(s):
- cyclophosphamide
- Route of administration: oral gavage
- Doses / concentrations: 25 mg/kg bw
Examinations
- Tissues and cell types examined:
- testes and bone marrow
Results and discussion
Test results
- Key result
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- Mortality was observed in the highest dose group. In the mid-dose group, a decrease in body weight was observed. Administration of the low and mid-dose caused hyperactivity in the test animals. No alterations on clinical or haematological parameters were observed. Females revealed reduced liver, brain and spleen weights. No gross anomalies were observed. No biologically or statistically significant compound-related effects on DNA repair were observed in the examined tissues.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
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