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Diss Factsheets
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EC number: 202-433-2 | CAS number: 95-57-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation (rabbit): corrosive
Eye irritation (rabbit): corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
- Remarks:
- (no details on study design and results provided)
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- To evaluate irritating properties towards the skin, the test substance was topically applied to the skin of six rabbits for 4 and 24 h. Local reactions were scored at 4, 24, 48, 72 und 168 h.
- GLP compliance:
- no
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot/batch No.of test material: KL 1003 - Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL
- Duration of treatment / exposure:
- 4 and 24 h
- Observation period:
- 21 days
Reading time points: 4, 24, 48, 72 and 168 h and daily afterwards until day 21 - Number of animals:
- 6
- Irritation parameter:
- other: erythema
- Basis:
- animal: 1 - 6
- Time point:
- other: 4 h
- Reversibility:
- not reversible
- Remarks on result:
- other: severe erythema were observed (no scores given).
- Irritation parameter:
- other: edema
- Basis:
- animal: 1-6
- Time point:
- other: 4 h
- Reversibility:
- not reversible
- Remarks on result:
- other: severe edema were observed.
- Irritant / corrosive response data:
- Topical application for 4 h resulted in severe erythema and edema. When the test substance was applied for 24 h, eschar formation was observed. Loosening about edges of scab after 17 - 21 days showed injury in depth.
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- CLP: Category 1
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
- Remarks:
- (no details on study design and results provided)
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- To evaluate the irritation potential towards the eyes, 0.1 mL test substance was instilled into the eyes of six rabbits for 1 min and 24 hrs. Irritation was determined at 1,24, 48, 72, 120 and 168 hours.
- GLP compliance:
- no
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: KL1003 - Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL - Duration of treatment / exposure:
- 1 min and 24 h
- Observation period (in vivo):
- 7 days
Reading time points: 1 min, 1, 24, 48, 72, 120 and 168 h - Number of animals or in vitro replicates:
- 6
- Irritation parameter:
- other: cornea
- Basis:
- animal: 1-6
- Time point:
- other: 1 min and 24 h
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive within 1 min
- Irritation parameter:
- other: iris
- Basis:
- animal: 1-6
- Time point:
- other: 1 min and 24 h
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive within 1 min
- Irritation parameter:
- other: conjuncitvae
- Basis:
- animal: 1-6
- Time point:
- other: 1 min and 24 h
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive within 1 min
- Irritant / corrosive response data:
- The undiluted test substance was corrosive within 1 minute after instillation.
- Other effects:
- - Other observations: Severe discomfort was observed after test substance instillation.
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- CLP: Category 1
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The skin irritancy potential of 2-chorophenol was determined in a skin irritation study in white rabbits (NZW) (reference 7.3.1-1). The test substance was topically applied to the skin of six rabbits for 4 and 24 h. Local reactions were scored at 4, 24, 48, 72 und 168 h. All animals showed signs of corrosion at all observation time points after application. In detail, topical application for 4 h resulted in severe erythema and edema. When the test substance was applied for 24 h, eschar formation was observed. Loosening about edges of scab after 17 - 21 days revealed injury in depth. Based on the results of the conducted study, 2-chlorophenol is considered as corrosive to the skin.
Eye irritation
To evaluate the irritation potential towards the eyes, 0.1 mL undiluted test substance was instilled into the eyes of six white rabbits (NZW) for 1 min and 24 h (reference 7.3.2-1). The reactions were observed 1, 24, 48, 72, 120 and 168 h after treatment. All animals showed signs of corrosion at all observation time points after application. Based on the results of the conducted study, 2-chlorophenol is considered as corrosive to the eyes.
Justification for classification or non-classification
The available data on skin and eye irritation meet the criteria for classification as Skin Corr. Cat. 1 (H314) and Eye Dam. Cat. 1 (H318) according to Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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