Registration Dossier

Administrative data

Description of key information

The oral LD50 of rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) was between 300 and 2000 mg/kg bw (OECD 423).

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
See chap. 13 read across justification
Reason / purpose:
read-across source
Related information:
Composition 1
Test material information:
Composition 1
Sex:
female
Dose descriptor:
LD50
Effect level:
> 300 - < 2 000 mg/kg bw
Based on:
act. ingr.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed

Additional information

The acute oral toxicity of rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) was determined to be 300 -2000 mg/kg bw (OECD 423). Thus, in accordance to the GHS (Globally Harmonised System), the substance (R)-1-(4-Methylphenyl)ethylamine should be classified in the hazard category 4.

Justification for classification or non-classification

Based on the available data for rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) (R)-1-(4-Methylphenyl)ethylamine is subject to C&L:

according to Regulation 1272/2008/EC: acute oral tox. 4, H302