Registration Dossier

Administrative data

Description of key information

Rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) showed a corrosive potential to the skin (OECD 431) and to the eyes (HET-CAM Test).

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
See chap. 13 read across justification
Reason / purpose:
read-across source
Related information:
Composition 1
Test material information:
Composition 1
Irritation / corrosion parameter:
other: cell viability
Value:
ca. 92
Remarks on result:
other: Basis: mean. Time point: 3 min. Reversibility:
Irritation / corrosion parameter:
other: cell viability
Value:
ca. 9
Remarks on result:
other: Basis: mean. Time point: 1 h. Reversibility:
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
See chap. 13 read across justification
Reason / purpose:
read-across source
Related information:
Composition 1
Test material information:
Composition 1
Remarks on result:
other: The undiluted test substance caused severe intravascular as well as extravascular coagulation and moderate haemorrhagia in all eggs within 9 – 12 seconds after application.
Remarks on result:
other: The 10% test-substance solution in olive oil Ph.Eur./DAB caused moderate intravascular coagulation in all eggs after 49 – 85 seconds and moderate haemorrhagia in all eggs within 11 – 17 seconds.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Additional information

Skin corrosion

Based on the results it was concluded, that rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) shows a corrosive potential in the EpiDerm skin corrosivity test. The test method does not yet allow for the differentiation of severity of the effect. The results however indicate moderate corrosivity. For final assignment of a risk phrase at present, further evidence or results from an in vivo study would be needed. [BASF, 2007]

Eye irritation

Based on the results it was concluded, that rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) caused serious eye damage in the HET-CAM Test under the test conditions. [BASF, 2007]

Justification for classification or non-classification

Based on the available data for rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) (R)-1-(4-Methylphenyl)ethylamine is subject to C&L:

according to Regulation 1272/2008/EC: skin corrosion cat. 1B, H314