Registration Dossier

Administrative data

Description of key information

(S)-1-(3-Methoxyphenyl)ethylamine (read across, CAS 82796-69-8) had a sensitizing effect on the skin of the guinea pig in the Maximization Test (OECD 406).

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
See chap. 13 read across justification
Reason / purpose:
read-across source
Related information:
Composition 1
Test material information:
Composition 1
Reading:
1st reading
Hours after challenge:
24
Group:
negative control
Dose level:
vehicle control
No. with + reactions:
0
Total no. in group:
5
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: vehicle control. No with. + reactions: 0.0. Total no. in groups: 5.0.
Reading:
2nd reading
Hours after challenge:
48
Group:
negative control
Dose level:
vehicle control
No. with + reactions:
0
Total no. in group:
5
Remarks on result:
other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: vehicle control. No with. + reactions: 0.0. Total no. in groups: 5.0.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

(S)-1-(3-Methoxyphenyl)ethylamine (read across, CAS 82796-69-8) was tested for its sensitizing effect on the skin of the guinea pig in the Maximization Test based on the method of Magnusson and Kligman. The study was performed using one control group and one test group. Based on the results it was concluded, that (S)-1-(3-Methoxyphenyl)ethylamine showed a strong sensitizing potential. [BASF, 2008]


Justification for classification or non-classification

Based on the available data for (S)-1-(3-Methoxyphenyl)ethylamine (read across, CAS 82796-69-8) (R)-1 -(4 -Methylphenyl)ethylamine is

subject to C&L:

according to Regulation 1272/2008/EC: sensitizing cat. 1A, H317