Registration Dossier
Registration Dossier
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EC number: 806-731-9 | CAS number: 1428353-74-5
Endpoint summary
Administrative data
Description of key information
Additional information
The registered substance is a borated ester alkyl amide that hydrolyzes in water to the original starting materials: boric acid, glycerol and coconut fatty acid diethanolamide. Acute fish and daphnia are available for the registered substance. Data for the hydrolysis products are also included; specifically the coconut fatty acid diethanolamide, which has a similar level of acute fish and daphnia toxicity as the registered substance, which is consistent with the hydrolysis.
The acute fish and daphnia data for the registered substance are as follows:
- Fish 96hr LC50: 10.2 mg/L
- Daphnia 48 hr EC50: 4.0 mg/L
This is very similar to data for the coconut fatty acid diethanolamide:
- Fish 96hr LC50: 2.6 mg/L (CAS 93-83-4, which is a similar material and is made from a C18 fatty acid instead of coconut fatty acid, which is a C12-18 alkyl chain)
- Daphnia 48 hr EC50: 2.15 mg/L (CAS 68603-42-9)
This data is from the FND Amide Category US EPA Hazard Characterization (September, 2010).
There is also sufficient acute and chronic aquatic toxicity data for boric acid (EPA, 2009) and glycerol (SIAR, 2002); these two substances are of low concern for aquatic toxicity. Therefore, the remaining data gaps are filled using aquatic toxicity for Amides, C12-18 and C18-unsatd., N, N-bis(hydroxyethyl) (CAS 90622-74-5). CAS 90622-74-5 is an appropriate analog material for the remaining hydrolysis product as both are fatty nitrogen derived amides. The results are as follows:
- OECD 201 (algae growth inhibition): EC50 of 7.4 mg/L (growth rate)
- OECD 215 (fish juvenile growth – 28D): NOEC of 0.32 mg/L (nominal) for mortality and growth
- OECD 211 (daphnia repro): 0.01-1.0 mg/L were tested resulting in a NOEC of 0.1 mg/L and a LOEC of 0.32 mg/L (both nominal) for survival and reproduction
In conclusion, based on the fact that hydrolysis occurs, which is supported by similar toxicity data between the registered substance and fatty acid diethanolamide, it is appropriate to use existing data from CAS 90622-74-5 to satisfy data gaps. As such, the chronic daphnia (OECD 211) study is chosen as the most sensitive study for classification and risk assessment purposes.
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