Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 238-262-5 | CAS number: 14320-04-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Zn-phthalocyanine is not expected to be sensitizing because Cu-phthalocaynine (CAS 147-14-8) is not sensitzing. Both substances are very poorly soluble in water (< 0.06 mg/L) and have a molecular weight of above 500 g/mol which interferes with permeability of the skin. ECHA guidance for assessing skin permeability indicate that although no general cut-off can be derived, substances with a log POW > 4 and a molecular weight of > 500 are assumed to be poorly absorbed (estimated uptatke 10%). The difficulty of achieving dermal exposure is documented by various publications on the potential use of Zn-phthaolcyanine as a therapeutic agent for photosensitization treatment of tumours (Love WG, 1997).
. Data on Cu-phthalocyanine indicated as valid without restriction is available from the dissemination view on the ECHA website and the registrant has also registered Cu-phthalocyanine.
Migrated from Short description of key information:
Zn-phthalocyanine is not expected to be sensitizing because Cu-phthalocaynine (CAS 147-14-8) is not sensitzing.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
