Registration Dossier
Registration Dossier
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EC number: 238-262-5 | CAS number: 14320-04-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation, but otherwise fulfills standard requirements.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (only 3 animals of the same sex per dose level were used, 2 instead of 3 dose levels, no details on test substance/animal husbandry)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]zinc
- EC Number:
- 238-262-5
- EC Name:
- [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]zinc
- Cas Number:
- 14320-04-8
- Molecular formula:
- C32 H16 N8 Zn
- Details on test material:
- - Batch No.: 77.89
No further details.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No data.
- Doses:
- 200, 2000 mg/kg bw
- No. of animals per sex per dose:
- 200 mg/kg bw: 3 female animals
2000 mg/kg bw: 3 male and 3 female animals - Control animals:
- not specified
- Details on study design:
- No data.
- Statistics:
- No data.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no mortalitiy was observed; animals suffered from piloerection, hunched posture, and dyspnea, but recovered within 4 to 5 days
- Mortality:
- No animal died.
- Clinical signs:
- other: Animals suffered from piloerection, hunched posture, and dyspnea, but recovered within 4 to 5 day.
- Gross pathology:
- At autopsy, no deviations from normal morphology were found.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No animal died or showed signs of intoxication upon a single oral dose of 2000 mg/kg bw.
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