Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Fatty acid methyl esters are efficiently metabolized in humans.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Metabolism

9-decenoic acid, methyl ester is a fatty acid methyl ester. Metabolism of short chain fatty acid methyl esters begins with hydrolysis of the ester, resulting in the carboxylic (e.g. fatty) acid and methanol. Methanol is oxidized to formaldehyde, which itself is oxidized to formic acid. Finally, formic acid is metabolized to CO2and H2O. Fatty acids are an important source of energy and adenosine triphosphate (ATP) for many cellular organisms. Fatty acids undergo β-oxidation, and the products enter physiological pathways like the citric acid cycle, sugar synthesis, and lipid synthesis.

Dermal Absorption

Using the US NIOSH Finite Dose Skin Permeation Calculator, systemic absorption of 9 -decenoic acid, methyl ester across partially hydrated human skin is predicted to be very low.