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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011-05-04 to 2011-08-11
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
Date of inspection 2011-07-19 to 2011-07-21; Date of certificate 2011-08-31
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
4.6
pH:
7.8
Remarks on result:
other: HPLC Column temperature: 40 deg. C
Details on results:
PRELIMINARY ESTIMATE
- Calculation of Log10 Pow resulted in a value of 4.17

DISCUSSION
- In the absence of any dissociating functional groups, no specific manipulation of the mobile phase pH was required to ensure that the test material was analysed in a molecular form.
Conclusions:
The partition coefficient of the test material was determined to be 3.98 x 10E4 (Log10 Pow = 4.60).

Description of key information

The partition coefficient of the test material was determined to be 3.98 x 10E4 (Log10 Pow = 4.60).

Key value for chemical safety assessment

Log Kow (Log Pow):
4.6
at the temperature of:
40 °C

Additional information

The partition coefficient of the test item was determined to be 3.98 x 104, log10Pow, using the HPLC method, designed to be compatible with Method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.