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EC number: 213-650-7 | CAS number: 998-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
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- Flash point
- Auto flammability
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- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
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- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11-02-1994 to 22-03-1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted according to the appropriate OECD test guideline and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Triethoxysilane
- EC Number:
- 213-650-7
- EC Name:
- Triethoxysilane
- Cas Number:
- 998-30-1
- Molecular formula:
- C6H16O3Si
- IUPAC Name:
- triethoxysilane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not reported.
- Age at study initiation: Young adult.
- Weight at study initiation: 3235 - 3389 g
- Housing: Individual suspended wire-mesh cages.
- Diet: Purina® Certified Rodent Chow® #5322 provided ad libitum
- Water: Municipal water were provided ad libitum
- Acclimation period: The animals were acclimated to laboratory conditions for a minimum of six days prior to initiation of dosing.
ENVIRONMENTAL CONDITIONS
- Temperature : 66-70°F
- Humidity (%): 32-70
- Photoperiod (hrs dark / hrs light): 12/ 12.
IN-LIFE DATES: From: 08-04-1994 To: 22-04-1994.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 days
Reading time points: 30-60 min, 24, 48, 72 h and daily to day 14. - Number of animals:
- 1 male and 2 females
- Details on study design:
- TEST SITE
- Area of exposure: One inch square patch on the back of the rabbit.
- % coverage: 20-25 %
- Type of wrap if used: Each 0.5 ml dose was applied under a 2-ply, one inch square gauze patch secured in place with surgical porous tape, that was overwrapped with a gauze binder and secured with Dermiform® tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The site was wiped with disposable paper towels moistened with deionised water.
- Time after start of exposure: 4 h
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d. Although very slight erythema persisted through study termination for a single animal this irritation was considered to be reversible.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 d.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 d
- Other effects:
- The test material induced moderate to slight erythema on two and one rabbits, respectively. All rabbits had very slight edema. Desquamation was noted for all rabbits by Day 5. Dermal irritation subsided by Day 14 for one animal. Desquamation persisted through Day 14 for two rabbits. Very slight erythema was present on Day 14 for one animal. There were no other dermal findings.
Any other information on results incl. tables
Table 1. Results of skin irritation study
Observation time |
Rabbit no. |
||||||
1 |
2 |
3 |
|||||
E* |
O* |
E |
O |
E |
O |
||
1 h |
2 |
1 |
2 |
1 |
2 |
1 |
|
24 h |
2 |
1 |
2 |
1 |
2 |
1 |
|
48 h |
3 |
1 |
3 |
0 |
2 |
1 |
|
72 h |
3 |
1 |
3 |
0 |
2 |
1 |
|
Mean value |
2.67 |
1.00 |
2.67 |
0.33 |
2.00 |
1.00 |
|
Mean value |
2.44 |
0.77 |
|
|
|
|
|
|
* E: erythema, O: oedema (according to Draize Score)
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal irritation/corrosion study conducted according to OECD 404 and GLP, the primary irritation index was calculated to be 3.1. The test material, triethoxysilane produced moderate, reversible dermal irritation under the conditions of this study and therefore classified as a Category II skin irritant (EU).
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