Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
partition coefficient
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Study period:
2011
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction
Principles of method if other than guideline:
The result was obtained using an appropriate QSAR method (see attached QMRF and QPRF for details).
GLP compliance:
no
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
-2.9
Temp.:
20 °C

Estimated value, no data available for temperature and pH

Conclusions:
A Log Kow of -2.9 was obtained for the substance using an appropriate calculation method. The result is considered to be reliable.
Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Study period:
2011
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction
Principles of method if other than guideline:
The result was obtained using an appropriate QSAR method (see attached QMRF and QPRF for details).
GLP compliance:
no
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
1.7
Temp.:
20 °C

Estimated value, no data available for temperature and pH

Conclusions:
A Log Kow of 1.7 was obtained for the substance using an appropriate calculation method. The result is considered to be reliable.

Description of key information

Partition coefficient (triethoxysilane): 1.7 (QSAR)
Partition coefficient (silanetriol): -2.9 (QSAR)
Log Kow (ethanol): -0.3

Key value for chemical safety assessment

Additional information

Due to the rapid hydrolysis of the substance (1 hr) the partition coefficient is not required. The Log Kow of 1.7 was obtained for the substance and -2.9 for the hydrolysis product using an appropriate calculation method. The result is considered to be reliable. Although, log Kow is not required for inorganic substances, the prediction is indicative of a high tendency to partition to water for the hydrolysis product.

Ethanol has a measured log Kow of -0.3 (Hansch C 1995).