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Description of key information

Skin sensitisation, patch test (key, RL2): sensitising

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vitro
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Sensitisation

No skin sensitisation studies in animals are available to evaluate the skin sensitizing properties of quinolin-8-ol (CAS 148-24-3). However, relevant information in humans is available that allow a final assessment of skin sensitising properties induced by quinolin-8-ol.

Skin sensitising properties of quinolin-8-ol (CAS 148-24-3) were determined in a human Patch test by topical application of the test substance (Pevny and Schellenberger, 1971). Three Patch tests were conducted with 100 or 127 patients. A positive sensitisation response was observed in all three tests. The indices of sensitivity (percentage of positive responses) were 4.7%, 8% and 6% in all 3 studies, respectively. Thus, quinolin-8-ol is considered to be an allergen in humans.

Furthermore, patients showed signs of contact allergy to quinolin-8-ol and to 8-hydroxyquinoline sulphate during dermatological therapies. In detail, in an epidermal test series for the determination of contact eczema caused by drugs within a period of six years, hypersensitivity to 8-hydroxyquinoline was observed in 3/450 patients indicating that quinolin-8-ol is a weak contact allergen. Furthermore, 8-hydroxyquinoline sulphate showed a positive response in one subject at concentrations above 0.01% and was considered as strong sensitiser (as cited in RAC opinion (Rothe, 1978; Metzner, 1987).

Overall conclusion

Based on the available data, human data provide evidence that quinolin-8-ol exhibits skin sensitisng properties by skin contact in a substantial number of people. Thus, quinolin-8-ol is considered as skin sensitizer. Due to limited information, sub-categorisation according to CLP criteria is not possible.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The available data on skin sensitization induced by quinolin-8-ol (CAS 148 -24 -3) meet the criteria for classification as Skin sens 1, H317 according to Regulation (EC) 1272/2008. Due to limited information, sub-categorisation according to CLP criteria is not possible.