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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Contact allergy to styrene with cross reaction to vinyltoluene
Author:
Sjöborg, S. et al.
Year:
1982
Bibliographic source:
Contact Dermatitis 8: 207-208
Reference Type:
secondary source
Title:
European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.
Author:
European Union
Year:
2007
Bibliographic source:
European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.

Materials and methods

Principles of method if other than guideline:
Guinea pig maximization test. No further details
GLP compliance:
no
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
The present study is sufficient to demonstrate the absence of a skin sensitizing potential. A LLNA is therefore not required.

Test material

Constituent 1
Chemical structure
Reference substance name:
Styrene
EC Number:
202-851-5
EC Name:
Styrene
Cas Number:
100-42-5
Molecular formula:
C8H8
IUPAC Name:
ethenylbenzene
Details on test material:
- Name of test material (as cited in study report): Styrene
- Analytical purity: no data

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
intradermal and epicutaneous
Vehicle:
other: acetone (challenge)
Concentration / amount:
induction: 10% intradermal, 20% topical
challenge: 2% w/v in acetone
Challengeopen allclose all
Route:
other: epicutaneous
Vehicle:
other: acetone (challenge)
Concentration / amount:
induction: 10% intradermal, 20% topical
challenge: 2% w/v in acetone
No. of animals per dose:
15
Details on study design:
no details available
Challenge controls:
no data
Positive control substance(s):
not specified

Results and discussion

In vivo (non-LLNA)

Results
Reading:
other: no data
Group:
test chemical
Dose level:
induction: 10% intradermal, 20% topical challenge: 2% w/v in acetone
No. with + reactions:
0
Total no. in group:
15
Clinical observations:
no data
Remarks on result:
other: Reading: other: no data. Group: test group. Dose level: induction: 10% intradermal, 20% topical challenge: 2% w/v in acetone. No with. + reactions: 0.0. Total no. in groups: 15.0. Clinical observations: no data.

Any other information on results incl. tables

None of the animals were sensitised. No further information available.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information