Registration Dossier
Registration Dossier
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EC number: 202-851-5 | CAS number: 100-42-5
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Short and long-term responses and recovery of mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene
- Author:
- Ruiz et al.
- Year:
- 2 014
- Bibliographic source:
- Ecotoxicology 23:861-879 (2014)
- Reference Type:
- review article or handbook
- Title:
- A critical review finds styrene lacks direct endocrine disruptor activity
- Author:
- Gelbke H.P., et al
- Year:
- 2 015
- Bibliographic source:
- Critical Reviews in Toxicology, 2015; Early Onlin: 1-38
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Investigation of impact of styrene (histopathological alterations and general stress responses) using a suite of biomarker
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Styrene
- EC Number:
- 202-851-5
- EC Name:
- Styrene
- Cas Number:
- 100-42-5
- Molecular formula:
- C8H8
- IUPAC Name:
- ethenylbenzene
Constituent 1
Results and discussion
Any other information on results incl. tables
Styrene concentrations in seawater ranged between 3 and 5 mg/L and tissue concentrations reached 19.3 mg/kg at day 7 and 21.6 mg/kg at day 19. After 2 weeks of recovery styrene was no longer detected indicating that in this species a bioacuumulation of styrene over time is not to be expected. Vitellogenin-like proteins and gamete development were not affected by exposure to styrene.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
