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Ecotoxicological information

Additional ecotoxological information

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Administrative data

Endpoint:
additional ecotoxicological information
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
2014
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No guideline study but but sufficiently described and documented

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Short and long-term responses and recovery of mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene
Author:
Ruiz et al.
Year:
2014
Bibliographic source:
Ecotoxicology 23:861-879 (2014)
Reference Type:
review article or handbook
Title:
A critical review finds styrene lacks direct endocrine disruptor activity
Author:
Gelbke H.P., et al
Year:
2015
Bibliographic source:
Critical Reviews in Toxicology, 2015; Early Onlin: 1-38

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Investigation of impact of styrene (histopathological alterations and general stress responses) using a suite of biomarker
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Styrene
EC Number:
202-851-5
EC Name:
Styrene
Cas Number:
100-42-5
Molecular formula:
C8H8
IUPAC Name:
ethenylbenzene

Results and discussion

Any other information on results incl. tables

Styrene concentrations in seawater ranged between 3 and 5 mg/L and tissue concentrations reached 19.3 mg/kg at day 7 and 21.6 mg/kg at day 19. After 2 weeks of recovery styrene was no longer detected indicating that in this species a bioacuumulation of styrene over time is not to be expected. Vitellogenin-like proteins and gamete development were not affected by exposure to styrene.

Applicant's summary and conclusion