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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Does not meet importent criteria of today standard methods. Study probably adequately conducted at the time (1969), however, only limited experimental details, not equivalent to modern guidelines.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Concentrations of Hydrocarbons in Tissues as a Measure of Toxicity
Author:
Shugaev, B.B.
Year:
1969
Bibliographic source:
Archives of Environmental Health 18: 878-882
Reference Type:
secondary source
Title:
European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.
Author:
European Union
Year:
2007
Bibliographic source:
European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.

Materials and methods

Principles of method if other than guideline:
Animals were placed into a dynamic flow exposure chamber. After removal from the flow chamber, the animals were sacrificed at different times as soon as they recovered from narcotic state.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Styrene
EC Number:
202-851-5
EC Name:
Styrene
Cas Number:
100-42-5
Molecular formula:
C8H8
IUPAC Name:
ethenylbenzene
Details on test material:
- Name of test material (as cited in study report): Styrene
- Physical state: vapour
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: no data
Analytical verification of test atmosphere concentrations:
yes
Remarks:
gas chromatography
Duration of exposure:
4 h
Concentrations:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
11.8 mg/L air
95% CL:
17.8 - 24.8
Exp. duration:
4 h

Any other information on results incl. tables

Table: Concentrations of Styrene found in brain and liver of rats

Time after removal from chamber (min)

Brain (mg/100 cm3)

Liver (mg/100 cm3)

Average of 4 experiments

Range

Average of 4 experiments

Range

1

21.8

14.8 – 30.1

20.2

11.3 – 29.7

15

22.2

13.5 – 31.6

23.5

12.9 – 32.0

30

17.7

10.7 – 22.4

19.1

14.2 – 29.0

60

8.6

3.3 – 14.7

12.8

5.7 – 20.2

90

Traces to 4.4

-

6.8

5.2 – 11.0

Applicant's summary and conclusion