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EC number: 202-851-5 | CAS number: 100-42-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Does not meet important criteria of today standard methods. Study probably adequately conducted at the time (1956), however, only limited experimental details; not equivalent to modern guidelines.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicological studies of certain alkylated benzenes and benzene.
- Author:
- Wolf, M.A. et al.
- Year:
- 1 956
- Bibliographic source:
- AMA Arch Ind Health 14: 387-398
- Reference Type:
- secondary source
- Title:
- European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.
- Author:
- European Union
- Year:
- 2 007
- Bibliographic source:
- European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.
Materials and methods
- Principles of method if other than guideline:
- Repeated occlusive skin application of 10-20 doses of undiluted styrene over 2-4 weeks to the ear and abdomen.
- GLP compliance:
- no
Test material
- Reference substance name:
- Styrene
- EC Number:
- 202-851-5
- EC Name:
- Styrene
- Cas Number:
- 100-42-5
- Molecular formula:
- C8H8
- IUPAC Name:
- ethenylbenzene
- Details on test material:
- - Name of test material (as cited in study report): Styrene
- Analytical purity: > 99%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: white rabbit
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Biochemical Research Department, Dow Chemical Company from a heterogenous stock
- Diet: commercial diet supplemented by alfalfa hay
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- 10 to 20 applications were made to the ear and onto the shaved abdomen over a period of two to four weeks
- Observation period:
- 2-4 weeks, observation daily
- Number of animals:
- no data
- Details on study design:
- Animals were observed daily and were weighed weekly.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: qualitative observation of erythema and necrosis
- Time point:
- other: after 2-4 weeks
- Score:
- > 0 - < 4
Any other information on results incl. tables
Moderate “definite erythema” with “slight necrosis” (development of a thin layer of devitalised tissue which resulted in exfoliation) on the surface skin. No other details are available. Numerical score not assignable.
Applicant's summary and conclusion
- Interpretation of results:
- other: not interpretable
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