Registration Dossier
Registration Dossier
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EC number: 202-851-5 | CAS number: 100-42-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The response of laboratory animals to monomere styrene
- Author:
- Spencer, H.C. et al.
- Year:
- 1 942
- Bibliographic source:
- The Journal of industrial hygiene and toxicology 24(10): 295-301
- Reference Type:
- secondary source
- Title:
- European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.
- Author:
- European Union
- Year:
- 2 007
- Bibliographic source:
- European risk assessment report, Styrene CAS No. 100-42-5, EINECS No. 202-851-5, Draft for submission to SCHER, November 2007.
Materials and methods
- Principles of method if other than guideline:
- Occlusive application of undiluted styrene to the rabbit abdomen.
- GLP compliance:
- no
Test material
- Reference substance name:
- Styrene
- EC Number:
- 202-851-5
- EC Name:
- Styrene
- Cas Number:
- 100-42-5
- Molecular formula:
- C8H8
- IUPAC Name:
- ethenylbenzene
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): monomeric Styrene
- Physical state: liquid
- Analytical purity: > 99%
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- other: qualitative observation of skin reaction
- Time point:
- other: unknown, after 2 applications
- Score:
- > 0 - < 4
- Remarks on result:
- other: Qualitative reporting only, numerical score not assignable.
Any other information on results incl. tables
"Marked irritation" with some denaturation.
Applicant's summary and conclusion
- Interpretation of results:
- other: not interpretable
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