Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 212-377-0 | CAS number: 811-97-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- An overview of the toxicology of HFA 134a (1,1,1,2-tetrafluoroethane)
- Author:
- Alexander DJ, Libretto SE
- Year:
- 1 995
- Bibliographic source:
- Human Exper Toxicol 14: 715 - 720
Materials and methods
Test material
- Reference substance name:
- Norflurane
- EC Number:
- 212-377-0
- EC Name:
- Norflurane
- Cas Number:
- 811-97-2
- Molecular formula:
- C2H2F4
- IUPAC Name:
- 1,1,1,2-tetrafluoroethane
Constituent 1
Test animals
- Species:
- guinea pig
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 3.0g
- Duration of treatment / exposure:
- Twice daily
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
HFC-134a vapour (3.0 g) was applied directly onto guinea pig skin, twice daily, using a metered dose device. No signs of irritation were reported.
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