Registration Dossier
Registration Dossier
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EC number: 212-377-0 | CAS number: 811-97-2
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study
Data source
Reference
- Reference Type:
- publication
- Title:
- An overview of the toxicology of HFA 134a (1,1,1,2-tetrafluoroethane)
- Author:
- Alexander DJ, Libretto SE
- Year:
- 1 995
- Bibliographic source:
- Human Exper Toxicol 14: 715 - 720
Materials and methods
Test material
- Reference substance name:
- Norflurane
- EC Number:
- 212-377-0
- EC Name:
- Norflurane
- Cas Number:
- 811-97-2
- Molecular formula:
- C2H2F4
- IUPAC Name:
- 1,1,1,2-tetrafluoroethane
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 6.0 g vapour
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 6.0 g vapour
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Executive summary:
HFC-134a vapour (6.0 g) was applied directly onto guinea pig skin for 6 days, using a metered dose device. The exposed site was then re-challenged with a further dose of 6.0 g HFC-134a after a period of 6 days. It is reported that HFC-134a showed essentially no signs of contact sensitisation potential, although it is unclear whether one of the standard skin sensitisation protocols was employed in this study.
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